A new geldanamycin analogue from Streptomyces hygroscopicus.
نویسندگان
چکیده
A new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. Compound 1 showed considerable cytotoxicity (SRB) against human cancer cell lines (breast cancer MCF-7, skin melanoma SK-MEL-2 and lung carcinoma COR-L23).
منابع مشابه
The description and antibiotic production of Streptomyces hygroscopicus var. Geldanus.
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عنوان ژورنال:
- Molecules
دوره 15 3 شماره
صفحات -
تاریخ انتشار 2010